In Grand Theft Auto VI, Ammu-Nation returns to Vice City and the broader state of Leonida with a fresh corporate identity. The franchise's in-game television commercials prominently feature Phil Cassidy, the classic firearms-obsessed character from past games, serving as the official face of the brand. Satirical advertisements broadcast across the game's map show a fully armed, two-armed Phil leaning heavily into over-the-top patriotic bravado to promote the weapon retailer to local residents.

Inside the store locations, players can access physical weapon racks stocked with assault rifles, shotguns, submachine guns, heavy artillery, and sidearms. Beyond buying weapons and body armor, racks display modular attachments such as suppressors, optical sights, and extended magazines for firearm customization. Larger branch locations also feature indoor shooting ranges where players can complete target challenges and upgrade shooting stats.